Molecular Mechanisms Controlling Vascular Lumen Formation in Three-Dimensional Extracellular Matrices
نویسندگان
چکیده
منابع مشابه
Molecular mechanisms controlling vascular lumen formation in three-dimensional extracellular matrices.
Considerable progress has been made toward a molecular understanding of how cells form lumen and tube structures in three-dimensional (3D) extracellular matrices (ECM). This progress has occurred through work performed with endothelial and epithelial cell models using both in vitro and in vivo approaches. Despite the apparent similarities between endothelial and epithelial cell lumen and tube f...
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Here we show a requirement for the Cdc42 and Rac1 GTPases in endothelial cell (EC) morphogenesis in three-dimensional extracellular matrices. Cdc42 and Rac1 specifically regulate EC intracellular vacuole and lumen formation in both collagen and fibrin matrices. Clostridium difficile toxin B (which blocks all three Rho GTPases) completely inhibited the ability of ECs to form both vacuoles and lu...
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Mechanical interactions between cells and extracellular matrix (ECM) mediate epithelial cyst formation. This work relies on the combination of numerical modeling with live cell imaging, to piece together a novel nonintrusive method for determining three-dimensional (3D) mechanical forces caused by shape changes of a multicellular aggregate at the early stages of epithelial cyst formation. We an...
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PURPOSE OF REVIEW The lumen of a blood vessel is essential for providing blood to any given tissue. Here, we discuss the molecular and cellular mechanisms underlying vascular lumen formation in invertebrates and vertebrates and highlight a new hypothesis describing oxygen transport in human malignant tumors. RECENT FINDINGS Several cellular mechanisms exist for blood vessel formation, that is...
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ژورنال
عنوان ژورنال: Cells Tissues Organs
سال: 2012
ISSN: 1422-6421,1422-6405
DOI: 10.1159/000331410